Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling

2023-05-10
Clinical Trial
Frontiers in Immunology 14
- Shujia Chen
- P. Han
- Qian Zhang
- Peiyan Liu
- Jie Liu
- Lili Zhao
- Lianyi Guo
- Jia Li

PubMed: 37234174
DOI: 10.3389/fimmu.2023.1179014

Improved Blood Glucose Levels

Low evidence
Animal Study

Accumulating evidence shows that Lactobacillus brevis can improve blood glucose and body weight of the T2DM mice model...

Effect: Beneficial
Effect size: Moderate
Significant: Yes

Influence of Lactobacillus brevis 15 and Lactobacillus plantarum 13 on blood glucose and body weight in rats after high-fructose diet.

2015-08
RCT · n = 24
Beneficial Microbes 6(4)
- M. Yakovlieva
- T. Tacheva
- S. Mihaylova
- R. Tropcheva
- K. Trifonova
- A. Toleкova
- Svetla Danova
- T. Vlaykova

PubMed: 25691100
DOI: 10.3920/BM2014.0012

5 Insights on

Improved Blood Glucose Levels

Low evidence
Animal Study

The final blood glucose levels had risen significantly in the groups receiving fructose either without (Fr; P<0.0001) or with lactobacilli (Pro+Fr; P=0.002), while the rise was insignificant in the group of rats given probiotic supplementation only (Pro, P=0.071) and inexistent in the Con group (P=0.999).

Effect: Beneficial
Effect size: Moderate
Significant: No