Lactobacillus brevis MAK11L82B and Reduced Despair-Like Behavior

• Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome

  • 2019-11-08
  • Clinical Trial
  • Scientific Reports 9(1)
  • • E. Patterson
    • E. Patterson
    • P. Ryan
    • P. Ryan
    • Niamh C Wiley
    • Niamh C Wiley
    • I. Carafa
    • I. Carafa
    • E. Sherwin
    • G. Moloney
    • E. Franciosi
    • R. Mandal
    • D. Wishart
    • D. Wishart
    • K. Tuohy
    • R. Ross
    • J. Cryan
    • Ted G. Dinan
    • C. Stanton
    • C. Stanton

  • PubMed: 31704943
  • DOI: 10.1038/s41598-019-51781-x

  4 Insights on

  • Reduced Despair-Like Behavior

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  Intervention with both L. brevis strains ... reduced despair-like behaviour and basal corticosterone production during the forced swim test

  Effect

  Beneficial

  Effect size

  Moderate