Lactobacillus brevis MAK11L82B and Reduced Myeloperoxidase Activity

• Lactobacillus brevis G‐101 ameliorates colitis in mice by inhibiting NF‐κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2‐like macrophages

  • 2013-07-01
  • Clinical Trial
  • Journal of Applied Microbiology 115(3)
  • • Se-Eun Jang
    • S. Hyam
    • M. Han
    • S. Kim
    • B.G. Lee
    • Dong-Hyun Kim

  • PubMed: 23742179
  • DOI: 10.1111/jam.12273

  3 Insights on

  • Reduced Myeloperoxidase Activity

  • Low evidence
  • Highly Cited
  • Animal Study

  Treatment with TNBS caused colon shortening; increased myeloperoxidase activity; and increased IL-1β, IL-6 and TNF-α expression in mice. Oral administration of Lact. brevis G-101 significantly inhibited these activities.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes