NapBiome trial: Targeting gut microbiota to improve sleep rhythm and developmental and behavioural outcomes in early childhood in a birth cohort in Switzerland - a study protocol.
- 2025-03
- RCT
- BMJ open 15(3)
- Petra Zimmermann
- Salome Kurth
- Stamatios Giannoukos
- Martin Stocker
- Nicholas A Bokulich
- PubMed: 40032396
- DOI: 10.1136/bmjopen-2024-092938
- High evidence
The study will investigate whether the administration of daily synbiotics or PLC for a duration of 3 months improves sleep patterns and neurodevelopmental outcomes up to 2 years of age.
- Effect
- Beneficial
- Effect size
- Moderate