Lactobacillus brevis SBC8803 and Improved Survival

• Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.

  • 2011-08-15
  • PloS one 6(8)
  • • Shuichi Segawa
    • Mikihiro Fujiya
    • Hiroaki Konishi
    • Nobuhiro Ueno
    • Naoyuki Kobayashi
    • Tatsuro Shigyo
    • Yutaka Kohgo

  • PubMed: 21858054
  • DOI: 10.1371/journal.pone.0023278

  3 Insights on

  • Improved Survival

  • Low evidence
  • Highly Cited

  Daily intrarectal administration of poly P (10 µg) improved the inflammation grade and survival rate in 4% sodium dextran sulfate-administered mice

  Effect

  Beneficial

  Effect size

  Moderate

• Heat‐killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function

  • 2011-11
  • Clinical Trial
  • Inflammatory Bowel Diseases 17(11)
  • • N. Ueno
    • M. Fujiya
    • S. Segawa
    • T. Nata
    • K. Moriichi
    • H. Tanabe
    • Y. Mizukami
    • N. Kobayashi
    • Kazutoshi Ito
    • Y. Kohgo

  • PubMed: 21987297
  • DOI: 10.1002/ibd.21597

  9 Insights on

  • Improved Survival

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study
  • Clinical

  these functions relieve intestinal impairments and improve the survival rate in mice with lethal colitis

  Effect

  Beneficial

  Effect size

  Moderate