Across 3 studies, all reported beneficial moderate-sized effects on reducing alcohol-induced liver injury in animal and cell models. No human studies were identified, and no statistically significant findings were reported. The evidence base is small and preliminary.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the included studies reached statistical significance — effect may be smaller than the predominant direction suggests. Additionally, the studies were conducted in animal models and cell lines, not in humans, limiting direct applicability.
GKLC1, GKS6, and GKM3 can be used as supplements for alleviating the development of ALD.
This review summarizes recent findings of how alcohol-induced alterations of gut microbiota and metabolome, and discusses the mechanistic link between gastrointestinal dyshomeostasis and alcoholic liver injury.
The treatment with Lactobacillus, whether as single-, or mixed-strain probiotics, was beneficial in reducing the severity of alcohol-induced liver injury likely through the increase in beneficial bacteria, and the reduction of inflammatory responses, and oxidative stress.
Lactic acid bacteria (LAB) strains, including Levilactobacillus brevis... were evaluated in ethanol-induced HepG2 cells. Among the evaluated LAB, nine strains increased aldehyde dehydrogenase (ALDH) levels and downregulated lipid peroxidation and liver transferase in the ethanol-induced HepG2 cells.
LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury.
oral administration of L. brevis significantly inhibited an increase in the level of serum ALT and AST... caused by ethanol intake