Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus brevis SBC8803 on reducing alcohol-induced liver injury. Evidence is derived from a mouse study, an in vitro cell study, and a review; no studies with statistically significant findings were reported. Doses and study durations were not consistently reported, and no human data were available.
Caveats: All evidence is from preclinical models (mice, cell lines) or a review; no human trials were available. None of the studies reported statistically significant findings, and sample sizes were small (e.g., n=6 for the mouse study). The relevance to human alcohol-induced liver injury remains uncertain.
GKLC1, GKS6, and GKM3 can be used as supplements for alleviating the development of ALD.
This review summarizes recent findings of how alcohol-induced alterations of gut microbiota and metabolome, and discusses the mechanistic link between gastrointestinal dyshomeostasis and alcoholic liver injury.
The treatment with Lactobacillus, whether as single-, or mixed-strain probiotics, was beneficial in reducing the severity of alcohol-induced liver injury likely through the increase in beneficial bacteria, and the reduction of inflammatory responses, and oxidative stress.
Lactic acid bacteria (LAB) strains, including Levilactobacillus brevis... were evaluated in ethanol-induced HepG2 cells. Among the evaluated LAB, nine strains increased aldehyde dehydrogenase (ALDH) levels and downregulated lipid peroxidation and liver transferase in the ethanol-induced HepG2 cells.
LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury.
oral administration of L. brevis significantly inhibited an increase in the level of serum ALT and AST... caused by ethanol intake