Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus brevis SBC8803 or related strains on reducing alcohol-induced liver injury. The evidence is predominantly from animal or in vitro models (mouse and HepG2 cells), with no human trials or consistently reported doses. Effect sizes were consistently moderate, but the evidence base is small and no statistically significant findings were reported.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the studies reported statistically significant findings, and the available research is limited to preclinical models (mice and cell lines), which may not translate to humans. Doses, forms, and study durations were not consistently reported, preventing dose-response or generalizability conclusions.
GKLC1, GKS6, and GKM3 can be used as supplements for alleviating the development of ALD.
This review summarizes recent findings of how alcohol-induced alterations of gut microbiota and metabolome, and discusses the mechanistic link between gastrointestinal dyshomeostasis and alcoholic liver injury.
The treatment with Lactobacillus, whether as single-, or mixed-strain probiotics, was beneficial in reducing the severity of alcohol-induced liver injury likely through the increase in beneficial bacteria, and the reduction of inflammatory responses, and oxidative stress.
Lactic acid bacteria (LAB) strains, including Levilactobacillus brevis... were evaluated in ethanol-induced HepG2 cells. Among the evaluated LAB, nine strains increased aldehyde dehydrogenase (ALDH) levels and downregulated lipid peroxidation and liver transferase in the ethanol-induced HepG2 cells.
LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury.
oral administration of L. brevis significantly inhibited an increase in the level of serum ALT and AST... caused by ethanol intake