Lactobacillus brevis SBC8803 and Reduced Neuroinflammation

• Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

  • 2022-11-23
  • Bioengineering & translational medicine 8(2)
  • • Hong-Xia Fan
    • Shuo Sheng
    • Dai-Di Li
    • Jing-Jie Li
    • Guo-Qing Wang
    • Feng Zhang

  • PubMed: 36925673
  • DOI: 10.1002/btm2.10455

  2 Insights on

  • Reduced Neuroinflammation

  • Low evidence

  heat-killed L. murinus reduced the activation of NLRP3 inflammasome in microglia and the secretion of pro-inflammatory factors, thus inhibiting the development of neuroinflammation

  Effect

  Beneficial

  Effect size

  Moderate

• Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease.

  • 2017-10-18
  • Scientific reports 7(1)
  • • Yodai Kobayashi
    • Hirosuke Sugahara
    • Kousuke Shimada
    • Eri Mitsuyama
    • Tetsuya Kuhara
    • Akihito Yasuoka
    • Takashi Kondo
    • Keiko Abe
    • Jin-Zhong Xiao

  • PubMed: 29044140
  • DOI: 10.1038/s41598-017-13368-2

  2 Insights on

  • Reduced Neuroinflammation

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  consumption of B. breve A1 suppressed the hippocampal expressions of inflammation and immune-reactive genes that are induced by amyloid-β

  Effect

  Beneficial

  Effect size

  Moderate