Lactobacillus brevis VPro 18 and Reduced Cancer Activity

• A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells

  • 2021-03-09
  • Probiotics and Antimicrobial Proteins 13(4)
  • • Mona Pourbaferani
    • Sima Modiri
    • A. Norouzy
    • H. Maleki
    • Mohadeseh Heidari
    • L. Alidoust
    • Venus Derakhshan
    • H. Zahiri
    • K. A. Noghabi

  • PubMed: 33687634
  • DOI: 10.1007/s12602-021-09766-8

  3 Insights on

  • Reduced Cancer Activity

  • Low evidence
  • Clinical

  The partially purified cell-secreted proteins of this strain (hereafter referred to as Lb-PPSPs) showed a time and dose-dependent anti-cancer and apoptosis induction function. There was a remarkable decline in the survival rate of MCF-7 cells at doses equal to and higher than 0.5 mg/mL after 48 h. The changes in expression of the three genes involved in the apoptosis pathway (BAX, BCL-2, and BCL2L11) in MCF-7 cells treated with the Lb-PPSPs confirm its cytotoxic activity and apoptosis induction.

  Effect

  Beneficial

  Effect size

  Moderate