Lactobacillus brevis VPro 18 and Reduced Intestinal Damage

• The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

  • 2020-06-09
  • Clinical Trial
  • Microorganisms 8(6)
  • • M. Marsova
    • M. Odorskaya
    • M. Novichkova
    • V. Polyakova
    • S. Abilev
    • E. Kalinina
    • A. Shtil
    • E. Poluektova
    • V. Danilenko

  • PubMed: 32527057
  • DOI: 10.3390/microorganisms8060876

  13 Insights on

  • Reduced Intestinal Damage

  • Low evidence
  • Rigorous Journal
  • Animal Study
  • Clinical

  The presence of damage to the intestine and the colon was determined by a morphometric analysis of specimens including the height of villi, the amount of goblet cells and infiltrating mononuclear cells, and the expression of the proliferative Ki-67 antigen. Oral administration of L.brevis 47 f strain prior to 5 FU decreased the drug-induced morphological and biochemical changes to their respective physiological levels.

  Effect

  Beneficial

  Effect size

  Moderate