Engineered Lactobacillus casei targets the IgT-pIgR axis to confer mucosal protection against Aeromonas veronii in snakehead (Channa argus).
- 2026-03-23
- Frontiers in immunology 17
- Kui-Peng Gao
- Jian-Ran Dou
- Bing-Bing Ma
- Tian-Bao Ma
- Na Li
- Ai-Dong Qian
- Xiao-Feng Shan
- Wu-Wen Sun
- Lei Zhang
- Di Zhang
- Chun-Feng Wang
- Dong-Xing Zhang
- PubMed: 41948342
- DOI: 10.3389/fimmu.2026.1759765
- Low evidence
- Animal Study
stimulated compartmentalized mucosal immunity, evidenced by a six-fold elevation in hindgut IgT transcripts, significant infiltration of IgT+ B cells, and pIgR mediated transcytosis
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes