Lactobacillus casei and Reduced Alcohol-Induced Liver Injury

• Lactobacillus casei culture supernatant ameliorates acute alcohol-induced liver injury by inhibiting cellular stress and promoting intestinal integrity in mice.

  • 2026-04-03
  • PloS one 21(4)
  • • Xie Zhang
    • Zhihui Xu
    • Ying You
    • Longteng Xie
    • Yongsheng Jiang
    • Junyue Chen
    • Zeping Xu
    • Feng Xu
    • Deshu Zhou

  • PubMed: 41931531
  • DOI: 10.1371/journal.pone.0344960

  2 Insights on

  • Reduced Alcohol-Induced Liver Injury

  • Low evidence
  • Animal Study

  L. casei supernatants supplementation significantly reduced alcohol-induced liver fat accumulation, inflammatory responses, intestinal mucosa injury, and improved liver function.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Alcohol-Induced Acute Liver Disease in Mice: A Comparison of the Preventive Effects of Fermented Milk from Lactobacillus delbrueckii Subsp. bulgaricus or Lacticaseibacillus casei.

  • 2026-04-07
  • Foods (Basel, Switzerland) 15(7)
  • • Mingzhen Liu
    • Weimei Kong
    • Tao Zhang
    • Zhen Wu
    • Xiaoqun Zeng
    • Yuxing Guo
    • Daodong Pan

  • PubMed: 41976554
  • DOI: 10.3390/foods15071260

  4 Insights on

  • Reduced Alcohol-Induced Liver Injury

  • Low evidence

  fermented milk was associated with reduced activation of TLR4/NF-κB pathways, alleviating alcohol-induced liver inflammation

  Effect

  Beneficial

  Effect size

  Moderate