Lactobacillus casei and Reduced Cerebral Ischemia/Reperfusion Injury

• Lactobacillus casei serves as a primary functional strain in fecal microbiota-mediated neuroprotection against cerebral ischemia/reperfusion injury.

  • 2026-06
  • Pathology, research and practice 282
  • • Li Niu
    • Yumin Tan
    • Wenlu Cao
    • Ermin Wang
    • Feng Qi

  • PubMed: 41946028
  • DOI: 10.1016/j.prp.2026.156441

  4 Insights on

  • Reduced Cerebral Ischemia/Reperfusion Injury

  • Low evidence

  Lactobacillus casei (L. casei) was identified as the predominant strain enriched by FMT... Both FMT and L. casei treatments restored serum ACh levels, upregulated α7nAChR expression, and increased anti-inflammatory immune cell infiltration, indicating CAIP activation. However, these neuroprotective effects were diminished by BenC, confirming dependence on cholinergic signaling.

  Effect

  Beneficial

  Effect size

  Large