Lactobacillus casei and Reduced Incidence of Abnormal Increase in Alkaline Phosphatase

• Lactobacillus casei alleviated the abnormal increase of cholestasis-related liver indices during tuberculosis treatment: a post hoc analysis of randomized controlled trial.

  • 2021-07-19
  • RCT · n = 429
  • Molecular Nutrition & Food Research 65(16)
  • • Ke Xiong
    • Jing Cai
    • Peiying Liu
    • Jinyu Wang
    • Shanliang Zhao
    • Lei Xu
    • Yang Yang
    • Jiahong Liu
    • A. Ma

  • PubMed: 33864432
  • DOI: 10.1002/mnfr.202100108

  9 Insights on

  • Reduced Incidence of Abnormal Increase in Alkaline Phosphatase

  • High evidence
  • Large Human Trial
  • Rigorous Journal

  The L. casei supplementation significantly reduced the incidence of the abnormal increase of cholestasis-related liver indices including alkaline phosphatase (p = 0.024)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1 × 10^10 colony-forming units (CFU) per day (low-dose group), or 2 × 10^10 CFU per day (high-dose group)