Lactobacillus casei and Reduced Interleukin-12 Level

Doses used in studies

CFU/day: 10 billion–20 billion (median 15 billion, IQR 10 billion–20 billion) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

1 of 1 paper

Lactobacillus casei modulates inflammatory cytokines and metabolites during tuberculosis treatment: A post hoc randomized controlled trial.

2022-03-01
RCT · n = 47
Asia Pacific journal of clinical nutrition 31(1)
- Lan Jiang
- Jinyu Wang
- Lei Xu
- Jing Cai
- Shanliang Zhao
- Aiguo Ma

PubMed: 35357105
DOI: 10.6133/apjcn.202203_31(1).0008

4 Insights on

Reduced Interleukin-12 Level

High evidence
Clinical

Daily Lactobacillus casei supplementation of up to 2 × 10^10 colony-forming units significantly lowered the concentrations of ... interleukin-12 (p<0.001)

Effect: Beneficial
Effect size: Small
Significant: Yes
Dose: 1 × 10^10 CFU/day (low-dose) or 2 × 10^10 CFU/day (high-dose)