Preterm-birth-prevention with Lactobacillus crispatus oral probiotics: Protocol for a double blinded randomised placebo-controlled trial (the PrePOP study).
- 2025-02
- RCT · n = 126
- Contemporary clinical trials 149
- Gillian A Corbett
- Siobhan Corcoran
- Conor Feehily
- Benedetta Soldati
- Anthony Rafferty
- David A MacIntyre
- Paul D Cotter
- Fionnuala M McAuliffe
- PubMed: 39701375
- DOI: 10.1016/j.cct.2024.107776
- High evidence
- Large Human Trial
This randomised trial will investigate ability of an oral probiotic containing L. crispatus to increase its abundance in the vaginal microbiome, both directly by horizontal transfer and indirectly via microbiome and metabolome of the gut.
- Effect
- Beneficial
- Effect size
- Small