Lactobacillus crispatus VPro 31 and Adhesion to Cervicovaginal Epithelial Cells

• Probiotic Properties of Lactobacillus crispatus 2,029: Homeostatic Interaction with Cervicovaginal Epithelial Cells and Antagonistic Activity to Genitourinary Pathogens

  • 2014-07-16
  • Probiotics and Antimicrobial Proteins 6(3-4)
  • • V. Abramov
    • V. Khlebnikov
    • I. Kosarev
    • Guldana Bairamova
    • R. Vasilenko
    • N. Suzina
    • A. Machulin
    • V. Sakulin
    • N. Kulikova
    • Nadezhda F. Vasilenko
    • A. V. Karlyshev
    • V. Uversky
    • M. Chikindas
    • V. Melnikov

  • PubMed: 25028263
  • DOI: 10.1007/s12602-014-9164-4

  15 Insights on

  • Adhesion to Cervicovaginal Epithelial Cells

  • Low evidence

  S-layers are responsible for the adhesion of lactobacilli on the surface of cervicovaginal epithelial cells. Study of interactions between L. crispatus 2029 and a type IV collagen, a major molecular component of epithelial cell extracellular matrix, showed that 125I-labeled type IV collagen binds to lactobacilli with high affinity (Kd = (8.0 ± 0.7) × 10(-10) M).

  Effect

  Beneficial

  Effect size

  Moderate