Lactobacillus crispatus VPro 31 and Reduced Th1/Th2 Ratio (IFN-γ/IL-4)

• Local Probiotic Lactobacillus crispatus and Lactobacillus delbrueckii Exhibit Strong Antifungal Effects Against Vulvovaginal Candidiasis in a Rat Model

  • 2019-05-08
  • Clinical Trial
  • Frontiers in Microbiology 10
  • • Ting Li
    • Zhaohui Liu
    • Xu Zhang
    • Xi Chen
    • Su-xia Wang

  • PubMed: 31139166
  • DOI: 10.3389/fmicb.2019.01033

  10 Insights on

  • Reduced Th1/Th2 Ratio (IFN-γ/IL-4)

  • Low evidence
  • Animal Study

  Our results indicated that Lactobacillus administration played an indispensable role in maintaining the immune homeostasis, and decreasing the Th1/Th2 ratio (IFN-γ/IL-4) by regulating the epithelial secretion of cytokines that inhibit epithelial proinflammatory cytokine release.

  Effect

  Beneficial

  Effect size

  Moderate