Lactobacillus crispatus and Improved Immune Surveillance

• Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa.

  • 2026-02-19
  • NPJ biofilms and microbiomes 12(1)
  • • Vanessa Croatti
    • Caroline Dricot
    • Tom Eilers
    • Jelle Dillen
    • Tim Van Rillaer
    • Eline Cauwenberghs
    • Ilke Van Tente
    • Sam Bakelants
    • Dieter Vandenheuvel
    • Camille Allonsius
    • Isabel Pintelon
    • Sofie Thys
    • Wendy Mensah
    • Marina Naldi
    • Peter A Bron
    • Stijn Wittouck
    • Irina Spacova
    • Carola Parolin
    • Beatrice Vitali
    • Sarah Lebeer

  • PubMed: 41714642
  • DOI: 10.1038/s41522-026-00937-5

  3 Insights on

  • Improved Immune Surveillance

  • Low evidence

  In a 3D vaginal organotypic model, EPS increased chemokines (CXCL5, CXCL6) linked to immune surveillance and the presence of the markers was validated in vaginal samples of healthy volunteers.

  Effect

  Beneficial

  Effect size

  Moderate