Lactobacillus crispatus and Reduced Recurrence of Bacterial Vaginosis

• Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial.

  • 2026-04
  • RCT
  • Cell host & microbe 34(4)
  • • Seth M Bloom
    • Laura Symul
    • Joseph Elsherbini
    • Jiawu Xu
    • Salina Hussain
    • Johnathan Shih
    • Ashley Sango
    • Caroline M Mitchell
    • Anke Hemmerling
    • Thomas P Parks
    • Aditi Kannan
    • Fatima A Hussain
    • Craig R Cohen
    • Susan P Holmes
    • Douglas S Kwon

  • PubMed: 41903526
  • DOI: 10.1016/j.chom.2026.03.003

  1 Insight on

  • Reduced Recurrence of Bacterial Vaginosis

  • High evidence

  LACTIN-V, a live biotherapeutic product (LBP) containing Lactobacillus crispatus strain CTV-05, significantly reduced recurrent BV in a phase 2b clinical trial, but efficacy was incomplete.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Regulatory Effects of Lactobacillus crispatus and Lactobacillus rhamnosus on the Formation and Composition of Gardnerella Biofilms.

  • 2026-03-02
  • Microorganisms 14(3)
  • • Hanyu Qin
    • Yun Liu
    • Sheng Yin
    • Zhengyuan Zhai
    • Bingbing Xiao

  • PubMed: 41900329
  • DOI: 10.3390/microorganisms14030569

  1 Insight on

  • Reduced Recurrence of Bacterial Vaginosis

  • Low evidence

  an important factor of BV recurrence is the persistent presence of Gardnerella biofilms... In contrast, a healthy vaginal microbiome, predominated by Lactobacillus, exerts protective effects by producing antimicrobial compounds that inhibit BV pathogen colonization and restore microbial homeostasis.

  Effect

  Beneficial

  Effect size

  Moderate