Lactobacillus delbrueckii and Improved Colitis Symptoms

• Lactobacillus delbrueckii surface protein P4430 attenuates intestinal inflammation by modulating macrophage polarization via Mincle.

  • 2026-02
  • Cell reports 45(2)
  • • Xiangyu Zhang
    • Xiangyi Zeng
    • Yujun Wu
    • Xiaoyi Liu
    • Xu Lin
    • Hao Wang
    • Yisi Liu
    • Luyuan Kang
    • Zhenyu Wang
    • Dongdong Lu
    • Xiaomei Liu
    • Guanhong Yue
    • Tengfei Lv
    • Shiyu Tao
    • Jinbiao Zhao
    • Zhaolai Dai
    • Guolong Zhang
    • Junjun Wang
    • Dandan Han

  • PubMed: 41569848
  • DOI: 10.1016/j.celrep.2025.116869

  2 Insights on

  • Improved Colitis Symptoms

  • Low evidence

  "P4430 reduces inflammation by binding to and inhibiting Mincle... [and] protects against intestinal inflammation"

  Effect

  Beneficial

  Effect size

  Moderate