Lactobacillus fermentum CECT5716 and Prolonged Pregnancy Duration

• Protocol for probiotic therapy vs placebo for preterm prelabour rupture of membranes to prolong pregnancy duration (Pro-PPROM) trial.

  • 2021-01-23
  • RCT
  • The Australian & New Zealand journal of obstetrics & gynaecology 61(2)
  • • Jonathan Sandeford
    • Tanya Nippita
    • Tushar Bhuta
    • Jillian Patterson
    • Jonathan Morris
    • Sean Seeho

  • PubMed: 33484479
  • DOI: 10.1111/ajo.13313

  1 Insight on

  • Prolonged Pregnancy Duration

  • High evidence
  • Pregnant Women

  The primary outcome will be the proportion of women still pregnant at seven days following PPROM. One-to-one randomisation will occur within 24 h of PPROM. The trial is powered (80%, alpha = 0.05) to detect an absolute percentage increase in the primary outcome of 30%, (from expected rate of 20% up to 50%).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  not stated