Lactobacillus fermentum CECT5716 and Reduced IL6 Production in Intestinal Epithelial Cells

• Different infant formulas can activate toll-like receptor 9 in vitro and inhibit interleukin 6 in human primary intestinal epithelial cells.

  • 2024-11-21
  • European journal of nutrition 64(1)
  • • Kathrin Hedegger
    • Theresa Hommel
    • Monika Schaubeck
    • Martina Gimpfl
    • Maik Dahlhoff

  • PubMed: 39567370
  • DOI: 10.1007/s00394-024-03507-7

  2 Insights on

  • Reduced IL6 Production in Intestinal Epithelial Cells

  • Low evidence
  • Rigorous Journal

  In P-IECs, the IFs induced increased phosphorylation of MAPK8/9 of the TLR signaling pathway and significantly reduced IL6 levels... L. fermentum CECT5716 and the here tested IFs could be a promising approach for modulation of gut health in infants.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes