Lactobacillus fermentum CECT5716 and Reduced Intestinal Inflammation

• Different infant formulas can activate toll-like receptor 9 in vitro and inhibit interleukin 6 in human primary intestinal epithelial cells.

  • 2024-11-21
  • European journal of nutrition 64(1)
  • • Kathrin Hedegger
    • Theresa Hommel
    • Monika Schaubeck
    • Martina Gimpfl
    • Maik Dahlhoff

  • PubMed: 39567370
  • DOI: 10.1007/s00394-024-03507-7

  2 Insights on

  • Reduced Intestinal Inflammation

  • Low evidence
  • Rigorous Journal

  L. fermentum CECT5716 enhanced TLR9-signaling and increased NF-kappa-B inhibitor alpha-phosphorylation... [and] reduce IL6 levels in human P-IECs through TLR9 activation.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The viability of Lactobacillus fermentum CECT5716 is not essential to exert intestinal anti-inflammatory properties.

  • 2016-03-01
  • Food & Function 6(4)
  • • A. Rodríguez‐Nogales
    • F. Algieri
    • T. Vezza
    • N. Garrido-Mesa
    • M. Olivares
    • M. Comalada
    • C. Riccardi
    • M. P. Utrilla
    • M. Rodríguez-Cabezas
    • J. Gálvez

  • PubMed: 25700085
  • DOI: 10.1039/c4fo00938j

  4 Insights on

  • Reduced Intestinal Inflammation

  • Low evidence

  both live and dead L. fermentum CECT5716 have been demonstrated to attenuate the inflammatory process and diminish the production of some of the inflammatory mediators

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes