Lactobacillus fermentum HA-179 and Improved Diabetic Foot Ulcer Healing

• Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics.

  • 2025-10-23
  • Review
  • Burns & trauma 14
  • • Aline Yen Ling Wang
    • Ana Elena Aviña
    • Yen-Yu Liu
    • Huang-Kai Kao

  • PubMed: 41550964
  • DOI: 10.1093/burnst/tkaf068

  2 Insights on

  • Improved Diabetic Foot Ulcer Healing

  • Low evidence

  a multi-cytokine-integrated strain of Lactococcus cremoris secreting FGF-2, IL-4, and CSF-1 promoted faster wound healing in diabetic mice and healed 83% of subjects in a Phase I DFU study

  Effect

  Beneficial

  Effect size

  Large