Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions.
- 2026-04
- Review
- Journal of advanced research 82
- Qiong Wu
- Guangqi Gao
- Lai-Yu Kwok
- Huimin Lv
- Zhihong Sun
- PubMed: 40651630
- DOI: 10.1016/j.jare.2025.07.005
- Low evidence
Probiotics and postbiotics are beneficial microorganisms and their components and metabolites, which offer potential in modulating the gut microbiota of the host and alleviating insomnia. ... Probiotics can regulate sleep-wake behavior by modulating gut microbiota and its metabolites, influencing endocrine, neuronal, and immune responses.
- Effect
- Beneficial
- Effect size
- Moderate