Lactobacillus fermentum VPro 14 and Restored Vaginal Flora

• Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women.

  • 2003-03
  • RCT · n = 64
  • FEMS Immunology & Medical Microbiology 35(2)
  • • G. Reid
    • D. Charbonneau
    • J. Erb
    • B. Kochanowski
    • D. Beuerman
    • Russ Poehner
    • A. Bruce

  • PubMed: 12628548
  • DOI: 10.1016/S0928-8244(02)00465-0

  11 Insights on

  • Restored Vaginal Flora

  • High evidence
  • Highly Cited
  • Adults

  Microscopy analysis showed restoration from asymptomatic bacterial vaginosis microflora to a normal lactobacilli colonized microflora in 37% women during lactobacilli treatment compared to 13% on placebo (P=0.02).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora.

  • 2001-12
  • RCT · n = 42
  • FEMS Immunology & Medical Microbiology 32(1)
  • • G. Reid
    • G. Reid
    • D. Beuerman
    • C. Heinemann
    • A. Bruce

  • PubMed: 11750220
  • DOI: 10.1111/J.1574-695X.2001.TB00531.X

  2 Insights on

  • Restored Vaginal Flora

  • High evidence
  • Highly Cited

  Treatment with L. rhamnosus GR-1/L. fermentum RC-14 once and twice daily correlated with a healthy vaginal flora in up to 90% of patients.

  Effect

  Beneficial

  Effect size

  Large