Lactobacillus gasseri and Reduced Ferroptosis

• Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway.

  • 2026-01-26
  • Chinese medicine 21(1)
  • • Cheng Cheng
    • Lei Zhu
    • Jingyi Hu
    • Wan Feng
    • Weiyang Li
    • Ryan Au
    • Yanan Li
    • Feng Xu
    • Yuguang Wu
    • Yuan Cui
    • Zhe Di
    • Bin Li
    • Yongchang Miao
    • Yao Lin
    • Lilin Ge
    • Hong Shen

  • PubMed: 41582187
  • DOI: 10.1186/s13020-025-01317-5

  2 Insights on

  • Reduced Ferroptosis

  • Low evidence

  L. gasseri was found to act as a novel ferroptosis inhibitor. In vitro studies confirmed that L. gasseri suppressed RSL3-induced ferroptosis in NCM-460 cells via activation of the GSH/GPX4 pathway.

  Effect

  Beneficial

  Effect size

  Moderate