Lactobacillus gasseri and Reduced Gastric Epithelial Proliferation Signaling

• Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells.

  • 2026-06
  • International journal of medical microbiology : IJMM 322
  • • Tanvi Somiah
    • Priyodip Paul
    • Sarah Pilheden
    • James Trumbo
    • Ann-Beth Jonsson

  • PubMed: 41401561
  • DOI: 10.1016/j.ijmm.2025.151694

  2 Insights on

  • Reduced Gastric Epithelial Proliferation Signaling

  • Low evidence

  in preincubation assays, L. gasseri downregulated the expression of ADAM17 and its substrates. Furthermore, the proliferation data demonstrated that L. gasseri suppressed H. pylori-induced cellular progression.

  Effect

  Beneficial

  Effect size

  Moderate