Lactobacillus helveticus R0052 and Increased Acetylcholine Levels

• Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway.

  • 2026-02
  • International immunopharmacology 171
  • • Chinasa Valerie Olovo
    • Ying Ji
    • Dickson Kofi Wiredu Ocansey
    • Xinxiang Huang
    • Min Xu

  • PubMed: 41512794
  • DOI: 10.1016/j.intimp.2025.116058

  4 Insights on

  • Increased Acetylcholine Levels

  • Low evidence
  • Animal Study

  052-MVs activated the cholinergic anti-inflammatory pathway (CAP) by upregulating α7 nAChR, acetylcholine (ACh), and the ACh-related enzymes choline acetyltransferase (ChAT) and acetylcholinesterase (AChE).

  Effect

  Beneficial

  Effect size

  Moderate