Lactobacillus helveticus R0052 and Reduced Colitis Severity

• Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway.

  • 2026-02
  • International immunopharmacology 171
  • • Chinasa Valerie Olovo
    • Ying Ji
    • Dickson Kofi Wiredu Ocansey
    • Xinxiang Huang
    • Min Xu

  • PubMed: 41512794
  • DOI: 10.1016/j.intimp.2025.116058

  4 Insights on

  • Reduced Colitis Severity

  • Low evidence
  • Animal Study

  052-MVs alleviated colitis symptoms, suppressed pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), increased the expression of anti-inflammatory cytokine (IL-10), enhanced the expression of tight junction proteins in colon tissues, and reduced macrophage polarization toward the M1 phenotype.

  Effect

  Beneficial

  Effect size

  Large