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Evidence-Based Supplement Research
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Lactobacillus helveticus Rosell-52 and Improved Cognitive Function

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus helveticus Rosell-52 on cognitive function, with effect sizes ranging from small to large. The only statistically significant finding came from a 2025 meta-analysis reporting a large beneficial effect (SMD -0.90, p=0.01) in patients with depression, while two narrative reviews noted small, inconsistent benefits, particularly in healthy populations with low baseline stress. Doses, forms, and study durations were not consistently reported, limiting dose-specific conclusions.

  • Studied populations: patients with depression

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only 1 of 3 studies reported a statistically significant finding; the two narrative reviews noted limited or inconsistent effects, suggesting that the large effect from the meta-analysis may not generalize, especially to healthy populations.

Generated May 12, 2026
3 of 3 papers
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