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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus helveticus Rosell-52 and Improved Cognitive Function

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on cognitive function, with one meta-analysis showing a large significant effect (SMD=-0.90, p=0.01). The predominant effect size is small to moderate overall, and the evidence comes primarily from a 2025 meta-analysis of 7 RCTs in patients with depression. No consistent dose or study duration was reported.

  • Studied populations: patients with depression (from the meta-analysis); adult humans in broader reviews

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The largest, most rigorous study (meta-analysis) was limited to patients with depression; applicability to healthy populations is unclear. Effect sizes ranged from small to large across studies.

Generated Jun 11, 2026
3 of 3 papers
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