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Evidence-Based Supplement Research
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Lactobacillus helveticus Rosell-52 and Improved Cognitive Function

Research synthesisModerate evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on cognitive function, but effect sizes varied (large in one meta-analysis, small in two reviews). Only one of three studies (the meta-analysis) reached statistical significance (p=0.01). The strongest evidence comes from a meta-analysis of RCTs in patients with depression; other reviews in general adult populations show limited effects.

  • Studied populations: adults with depression

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Only one of three studies reported a statistically significant finding, and that meta-analysis showed high heterogeneity (I²=82%) and examined probiotics broadly rather than exclusively L. helveticus Rosell-52, so effects may not be specific to this strain. No dose or form data were available.

Generated Jul 12, 2026
3 of 3 papers
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