Lactobacillus helveticus Rosell-52 and Reduced Anxiety

• Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis.

  • 2026-03-27
  • Review
  • Frontiers in microbiology 17
  • • Natarajan Sisubalan
    • Periyanaina Kesika
    • Bhagavathi Sundaram Sivamaruthi
    • Chaiyavat Chaiyasut

  • PubMed: 41971341
  • DOI: 10.3389/fmicb.2026.1804560

  7 Insights on

  • Reduced Anxiety

  • Low evidence

  clinical trials investigating strains such as Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus gasseri, and multi-strain formulations have demonstrated strain- and context-specific effects on psychological and physiological outcomes. While some studies reported improvements in mood, anxiety, sleep quality, and cognitive performance

  Effect

  Beneficial

  Effect size

  Moderate

• Probiotics for Anxiety and Depressive Symptoms in Cancer: A Systematic Review of Animal and Human Studies with Mechanistic Insights.

  • 2025-12-25
  • Review
  • Microorganisms 14(1)
  • • Zahra Amirkhanzadeh Barandouzi
    • Deborah Watkins Bruner
    • Yufen Lin
    • Hannah Choi
    • Layla R Zeki
    • Tobi Akangbe
    • Amruta Epari
    • Hongjin Li

  • PubMed: 41597571
  • DOI: 10.3390/microorganisms14010051

  6 Insights on

  • Reduced Anxiety

  • Low evidence

  Some trials reported improvements in anxiety, and depressive symptoms, while others showed no significant differences compared with control groups.

  Effect

  Beneficial

  Effect size

  Small