Lactobacillus helveticus and Enhanced Immune Response

• Surface Layer-Associated Protein on Nanoparticles from Lactobacillus helveticus Enhances the Response to LPS in RAW264.7 Cells.

  • 2026-02-21
  • Current microbiology 83(4)
  • • Chika Yamamoto
    • Nao Fujiwara
    • Ika Adhani Sholihah
    • Mana Yamamoto
    • Rinka Kizaki
    • Daichi Ito
    • Chinatsu Yokoi
    • Saho Furukawa
    • Hiroko Koyama
    • Yoko Hirata
    • Kyoji Furuta
    • Hiroshi Takemori

  • PubMed: 41721904
  • DOI: 10.1007/s00284-026-04783-8

  2 Insights on

  • Enhanced Immune Response

  • Low evidence
  • Animal Study

  SLAP was added to the culture medium, either in the form of EV-LNPs or as a purified protein. Notably, L. helveticus EV-LNPs were internalized within 3 h and enhanced NF-κB signaling in response to lipopolysaccharide. Intracellular overexpression of SLAP led to increased activity of the inducible nitric oxide synthase promoter about 1.5 times... Incubation of RAW264.7 cells with EV-LNPs or SLAP enhanced the uptake of Escherichia coli.

  Effect

  Beneficial

  Effect size

  Moderate