Lactobacillus jensenii LJe52 and Enhanced Negative Regulation of TLR Activity

• Immunobiotic Lactobacillus jensenii Elicits Anti-Inflammatory Activity in Porcine Intestinal Epithelial Cells by Modulating Negative Regulators of the Toll-Like Receptor Signaling Pathway

  • 2012-01
  • Infection and Immunity 80(1)
  • • T. Shimazu
    • J. Villena
    • M. Tohno
    • Hitomi Fujie
    • Shoichi Hosoya
    • T. Shimosato
    • H. Aso
    • Y. Suda
    • Y. Kawai
    • Tadao Saito
    • Seiya Makino
    • S. Ikegami
    • H. Itoh
    • H. Kitazawa

  • PubMed: 22083706
  • DOI: 10.1128/IAI.05729-11

  4 Insights on

  • Enhanced Negative Regulation of TLR Activity

  • Low evidence
  • Highly Cited

  Furthermore, we demonstrated that L. jensenii TL2937 stimulation of PIE cells upregulated three negative regulators of TLRs: A20, Bcl-3, and MKP-1, deepening the understanding of an immunobiotic mechanism of action.

  Effect

  Beneficial

  Effect size

  Moderate