Lactobacillus johnsonii LJ09 and Increased Paneth Cell Number in Intestinal Crypts

• Lactobacillus johnsonii N6.2 stimulates the innate immune response through Toll-like receptor 9 in Caco-2 cells and increases intestinal crypt Paneth cell number in biobreeding diabetes-prone rats.

  • 2011-06
  • Clinical Trial
  • The Journal of Nutrition 141(6)
  • • S. Kingma
    • Nan Li
    • F. Sun
    • Ricardo B. Valladares
    • J. Neu
    • G. Lorca

  • PubMed: 21490291
  • DOI: 10.3945/jn.110.135517

  2 Insights on

  • Increased Paneth Cell Number in Intestinal Crypts

  • Low evidence
  • Highly Cited
  • Animal Study

  Activation of TLR9 was also evidenced by increased Frizzled 5 expression in Ljo-treated Caco-2 cells and an increase in the number of Paneth cells in Ljo-fed, diabetes-prone rats.

  Effect

  Beneficial

  Effect size

  Large