Lactobacillus johnsonii VPro 33 and Reduced Indoleamine 2,3-Dioxygenase Activity

• Lactobacillus johnsonii inhibits indoleamine 2,3‐dioxygenase and alters tryptophan metabolite levels in BioBreeding rats

  • 2013-01-09
  • Clinical Trial
  • The FASEB Journal 27(4)
  • • Ricardo B. Valladares
    • Lora Bojilova
    • Anastasia H. Potts
    • E. Cameron
    • Christopher L. Gardner
    • G. Lorca
    • Claudio F. Gonzalez

  • PubMed: 23303207
  • DOI: 10.1096/fj.12-223339

  4 Insights on

  • Reduced Indoleamine 2,3-Dioxygenase Activity

  • Low evidence
  • Highly Cited
  • Animal Study

  L. johnsonii CFS significantly reduced IDO activity in HT-29 intestinal epithelial cells (47% reduction) compared with that in vehicle-treated controls, an effect abolished by catalase treatment.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes