Lactobacillus johnsonii and Reduced Hepatocellular Carcinoma Recurrence

• Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T-cell Expansion in Hepatocellular Carcinoma.

  • 2026-01-22
  • Observational
  • Cancer research 86(8)
  • • Qianshi Liu
    • Yiqiang Liu
    • Yue Zhou
    • Liang Liang
    • Yejian Wan
    • Ying Wang
    • Ting Huang
    • Ling Zhong
    • Zhaoshen Li
    • Tao Luo
    • Ming Zhao
    • Zhe-Xuan Li
    • Yu-Cong Li
    • Hai-Tao Lan
    • Hong Wu
    • Chuan Xu
    • Jie Chen

  • PubMed: 41570324
  • DOI: 10.1158/0008-5472.can-25-0346

  3 Insights on

  • Reduced Hepatocellular Carcinoma Recurrence

  • Low evidence

  Lactobacillus johnsonii and its metabolite NA enrich intratumoral IFNγ+PD-1+CD8+ T cells, thereby reshaping the immune microenvironment to potentiate immunotherapy efficacy and suppress HCC recurrence.

  Effect

  Beneficial

  Effect size

  Large