Lactobacillus johnsonii and Reduced Neuroinflammation

• Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation.

  • 2026-04
  • Pharmacological research 226
  • • Jing Xie
    • Yongzhi Zhang
    • Jiao-Lin Wang
    • Fei He
    • Ke Xu
    • Jianjun Chen
    • Peng Xie

  • PubMed: 41825730
  • DOI: 10.1016/j.phrs.2026.108158

  3 Insights on

  • Reduced Neuroinflammation

  • Low evidence
  • Animal Study

  both treatments significantly elevated IPA levels in peripheral and central samples, and improved the mRNA levels of AhR and NF-κB p65 in hippocampus. Critically, the antidepressant effects of L. johnsonii and IPA were counteracted by AhR antagonist CH223191

  Effect

  Beneficial

  Effect size

  Moderate