Lactobacillus paracasei MCC1849 and Increased Follicular Helper T Cell Activity

• Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice

  • 2018-06-13
  • Clinical Trial
  • PLOS ONE 13(6)
  • • S. Arai
    • N. Iwabuchi
    • Sachiko Takahashi
    • J. Xiao
    • F. Abe
    • S. Hachimura

  • PubMed: 29897995
  • DOI: 10.1371/journal.pone.0199018

  3 Insights on

  • Increased Follicular Helper T Cell Activity

  • Low evidence
  • Rigorous Journal
  • Animal Study

  MCC1849 increased the proportion of IgA+ B cells and Tfh cells in Peyer's patches (PPs).

  Effect

  Beneficial

  Effect size

  Moderate