Lactobacillus paracasei MCC1849 and Increased Immune System Activation

• Effects of Heat-Killed Lacticaseibacillus paracasei MCC1849 on Immune Parameters in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.

  • 2024-01-09
  • RCT · n = 49
  • Nutrients 16(2)
  • • Kumiko Kato
    • Satoshi Arai
    • Soichiro Sato
    • Noriyuki Iwabuchi
    • Tsuyoshi Takara
    • Miyuki Tanaka

  • PubMed: 38257109
  • DOI: 10.3390/nu16020216

  1 Insight on

  • Increased Immune System Activation

  • High evidence
  • Rigorous Journal

  The expression level of CD86 on pDCs and the gene expression levels of IFN-α, -β, and -γ upon TLR9 agonist stimulation were significantly higher in the MCC1849 group at 4 weeks.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Immunomodulatory activity of heat-killed Lacticaseibacillus paracaseiMCC1849 based on the activation of plasmacytoid dendritic cells in the peripheral blood of healthy adults.

  • 2024-02-07
  • Food science & nutrition 12(5)
  • • Yiran Li
    • Takahiro Aoki
    • Sadahiro Iwabuchi
    • Satoshi Arai
    • Noriyuki Iwabuchi
    • Hideki Motobayashi
    • Miyuki Tanaka
    • Shinichi Hashimoto

  • PubMed: 38726445
  • DOI: 10.1002/fsn3.4009

  2 Insights on

  • Increased Immune System Activation

  • Low evidence

  hk-MCC1849 significantly increased the expression of the plasmacytoid dendritic cell (pDC) marker CD86 ... and the pDC marker HLA-DR ... The expression levels of the IL-12p40, IFNα, IFNα1, IFNγ, and ISG15 genes were significantly increased after coculture with hk-MCC1849

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes