Lactobacillus paracasei SD5275 and Reduced Duration of Mechanical Ventilation

Doses used in studies

CFU/day: 2 billion (median 2 billion, IQR 2 billion–2 billion) — 1 study

Time to effect

Median: 5 days · IQR 5 days–5 days · Range 5 days–5 days — Reported in 1 of 1 study

1 of 1 paper

Effects of probiotic supplementation on infectious and gastrointestinal complications of critically ill patients: Randomized, blinded, placebo-controlled clinical trial.

2025-08
RCT · n = 70
Clinical nutrition ESPEN 68
- Janaina Bach Naslowski
- Maria Eliana Madalozzo Schieferdecker
- Antonio Carlos Ligocki Campos

PubMed: 40345657
DOI: 10.1016/j.clnesp.2025.05.006

8 Insights on

Reduced Duration of Mechanical Ventilation

High evidence
Clinical

Although the number of days on mechanical ventilation, ICU stay, and mortality were lower in the patients who received probiotics, no significant differences were observed between the groups (p ≥ 0.05).

Effect: Neutral
Effect size: Small
Significant: No
Dose: 2×10^9 CFU/day