Lactobacillus paracasei VPro 224 and Enhanced Endoplasmic Reticulum Stress Response

• Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway

  • 2020-03
  • Clinical Trial
  • Experimental & Molecular Medicine 52(3)
  • • J. Choi
    • C. Moon
    • Tae-Seop Shin
    • Eun Kyoung Kim
    • Andrea McDowell
    • Min-Kyung Jo
    • Y. Joo
    • Seong-Eun Kim
    • Hye-Kyung Jung
    • K. Shim
    • S. Jung
    • Yoon-Keun Kim

  • PubMed: 32123288
  • DOI: 10.1038/s12276-019-0359-3

  15 Insights on

  • Enhanced Endoplasmic Reticulum Stress Response

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  In addition, LpEVs induced the expression of endoplasmic reticulum (ER) stress-associated proteins, while the inhibition of these proteins blocked the anti-inflammatory effects of LpEVs in LPS-treated HT29 cells, restoring the pro-inflammatory effects of LPS.

  Effect

  Beneficial

  Effect size

  Moderate