Lactobacillus paracasei VPro 224 and Reduced Gardnerella Vaginosis Prevalence

• Effect of oral consumption of capsules containing Lactobacillus paracasei LPC-S01 on the vaginal microbiota of healthy adult women: a randomized, placebo-controlled, double-blind crossover study

  • 2020-05-08
  • RCT · n = 40
  • FEMS Microbiology Ecology 96(6)
  • • R. Koirala
    • G. Gargari
    • S. Arioli
    • Valentina Taverniti
    • W. Fiore
    • E. Grossi
    • G. Anelli
    • I. Cetin
    • S. Guglielmetti

  • PubMed: 32383767
  • DOI: 10.1093/femsec/fiaa084

  4 Insights on

  • Reduced Gardnerella Vaginosis Prevalence

  • High evidence
  • Rigorous Journal
  • Adults

  Statistical modeling (including linear mixed-effects model analysis) demonstrated that daily intake of probiotic capsules reduced the relative abundance of Gardnerella spp. Quantitative PCR with Gardnerella vaginalis primers confirmed this result. Considering the pathogenic nature of G. vaginalis, these results suggest a potential positive effect of this probiotic capsule on the vaginal microbial ecosystem.

  Effect

  Beneficial

  Effect size

  Moderate