Lactobacillus paracasei VPro 224 and Reduced Pro-Inflammatory Cytokines

• Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway

  • 2020-03
  • Clinical Trial
  • Experimental & Molecular Medicine 52(3)
  • • J. Choi
    • C. Moon
    • Tae-Seop Shin
    • Eun Kyoung Kim
    • Andrea McDowell
    • Min-Kyung Jo
    • Y. Joo
    • Seong-Eun Kim
    • Hye-Kyung Jung
    • K. Shim
    • S. Jung
    • Yoon-Keun Kim

  • PubMed: 32123288
  • DOI: 10.1038/s12276-019-0359-3

  15 Insights on

  • Reduced Pro-Inflammatory Cytokines

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  LpEVs reduced the expression of the LPS-induced pro-inflammatory cytokines IL-1α, IL-1β, IL-2, and TNFα and increased the expression of the anti-inflammatory cytokines IL-10 and TGFβ.

  Effect

  Beneficial

  Effect size

  Moderate