Lactobacillus plantarum 14D and Reduced Ulcerative Colitis Symptoms

• Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies.

  • 2026-03-17
  • Review
  • Frontiers in microbiology 17
  • • Chao Niu
    • Jing Wang
    • Xinping Lu
    • Yongduo Yu

  • PubMed: 41924481
  • DOI: 10.3389/fmicb.2026.1787284

  1 Insight on

  • Reduced Ulcerative Colitis Symptoms

  • Low evidence

  This review synthesizes evidence that probiotics mitigate UC through multiple synergistic mechanisms: competitive exclusion to rebalance the microbiota, upregulation of tight junction proteins to restore the intestinal barrier, and bidirectional immunomodulation to restrain excessive inflammation.

  Effect

  Beneficial

  Effect size

  Moderate