Lactobacillus plantarum 299v and Improved Quality of Life

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, 3 reported beneficial effects on quality of life, with 1 of those finding a statistically significant result. The predominant effect size is moderate, but the evidence is limited by small sample sizes and mixed statistical significance. The most studied populations are cancer patients receiving home enteral nutrition and patients with IBS.

Studied populations: Cancer patients receiving home enteral nutrition; patients with IBS

Caveats: Only 3 studies were available, and 2 of them had small sample sizes (21–35 participants). The only statistically significant finding came from an observational study, not an RCT. Dosing information was not reported in any of the studies, limiting dose-response conclusions.

Generated May 10, 2026

3 of 3 papersPopulation:

The use of Lactobacillus plantarum 299v (DSM 9843) in cancer patients receiving home enteral nutrition – study protocol for a randomized, double-blind, and placebo-controlled trial
- 2020-09-11
- RCT
- Nutrition Journal 19(1)
- - Karolina Kaźmierczak-Siedlecka
  - Marcin Folwarski
  - Karolina Skonieczna-Żydecka
  - Jakub Ruszkowski
  - Wojciech Makarewicz
- PubMed: 32917221
- DOI: 10.1186/s12937-020-00598-w
6 Insights on
- Improved Quality of Life
- High evidence
- Clinical
Thus, administration of Lactobacillus plantarum 299v may be effective in improvement of... quality of life of cancer patients receiving home enteral nutrition.
Effect
Beneficial
Effect size
Moderate
[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].
- 2021-02
- Observational · n = 221
- Zeitschrift fur Gastroenterologie 59(02)
- - Heiner Krammer
  - Martin Storr
  - Ahmed Madisch
  - Julia Riffel
- PubMed: 33556972
- DOI: 10.1055/a-1340-0204
6 Insights on
- Improved Quality of Life
- High evidence
Additionally, quality of life increased significantly (mental well-being: + 110 %, influence on everyday life: -67 %, p < 0.01).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition - a double-blind, randomized, and placebo-controlled trial.
- 2020-09-01
- RCT · n = 21
- European review for medical and pharmacological sciences 24(18)
- - K Kaźmierczak-Siedlecka
  - M Folwarski
  - J Ruszkowski
  - K Skonieczna-Żydecka
  - W Szafrański
  - W Makarewicz
- PubMed: 33015813
- DOI: 10.26355/eurrev_202009_23059
5 Insights on
- Improved Quality of Life
- High evidence
The improvement of quality of life was observed in both groups; however, with no statistically significant differences between the analyzed groups (p>0.05).
Effect
Beneficial
Effect size
Small
Significant
No

Lactobacillus plantarum 299v and Improved Quality of Life

The use of Lactobacillus plantarum 299v (DSM 9843) in cancer patients receiving home enteral nutrition – study protocol for a randomized, double-blind, and placebo-controlled trial

[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].

Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition - a double-blind, randomized, and placebo-controlled trial.