Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study.
- 2019-02
- RCT · n = 40
- Psychoneuroendocrinology 100
- Leszek Rudzki
- Lucyna Ostrowska
- Dariusz Pawlak
- Aleksandra Małus
- Krystyna Pawlak
- Napoleon Waszkiewicz
- Agata Szulc
- PubMed: 30388595
- DOI: 10.1016/j.psyneuen.2018.10.010
- High evidence
- Highly Cited
- Clinical
The severity of psychiatric symptoms was assessed using Hamilton Depression Rating Scale (HAM-D 17) ... There was an improvement ... in the LP299v group compared with the placebo between baseline and after 8 weeks of intervention. [Abstract indicates no significant difference for HAM-D, only for cognitive tests]
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- not specified