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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus plantarum HEAL9 and Improved Cognitive Function

Research synthesisVery low evidenceSmall effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported small beneficial effects of Lactobacillus plantarum HEAL9 on cognitive function. One meta-analysis (n=390) found statistically significant improvements on MMSE and MoCA, though the certainty of evidence was low. The remaining RCT (n=66) showed a trend toward improvement that did not reach statistical significance. Evidence is very preliminary, with no consistent dose or duration data available.

  • Studied populations: Adults over 18 years (meta-analysis); older adults >70 years with chronic low-grade inflammation (RCT)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The one statistically significant finding came from a meta-analysis rated as low certainty; the single RCT did not reach significance. Study durations and doses were not consistently reported. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated May 12, 2026
Doses used in studies
  • CFU/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study
3 of 3 papers
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