Lactobacillus plantarum HEAL9 and Improved Cognitive Function

• Efficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.

  • 2025-11-25
  • Meta-Analysis · n = 390
  • BMC complementary medicine and therapies 25(1)
  • • Nancy Calzada-Gonzales
    • Ismael Moreno-Colina
    • Linn Chu-Fuentes
    • Daniel Andrade-Girón
    • Hugo E Tito-Chura
    • Carlos Quispe-Vicuña
    • Pedro I Torres-Balarezo
    • Anthony Bautista-Pariona
    • Joshuan J Barboza

  • PubMed: 41291638
  • DOI: 10.1186/s12906-025-05149-6

  3 Insights on

  • Improved Cognitive Function

  • High evidence

  Limited evidence suggests a possible improvement in cognitive function from probiotics use at 12 weeks (MD 4.23, 95% CI 2.77 to 5.68; certainty of evidence (CoE) was low, I² = 0%) for MMSE and cognitive function (MD 1.21; 95% CI 0.06 to 2.36; certainty of evidence (CoE) was low; I² = 35%) for MoCA; however, due to the very low certainty found, the evidence is very uncertain.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

  • 2024-06-19
  • RCT · n = 66
  • Probiotics and antimicrobial proteins 17(5)
  • • Irini Lazou-Ahrén
    • Malin Björklund
    • Göran Molin
    • Jie Xu
    • Gunilla Önning
    • Sölve Elmståhl
    • Bengt Jeppsson

  • PubMed: 38896223
  • DOI: 10.1007/s12602-024-10310-7

  2 Insights on

  • Improved Cognitive Function

  • High evidence
  • Rigorous Journal

  Both probiotic groups showed a trend in improving cognitive function albeit not reaching statistical significance.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No

• The gut-brain axis in Alzheimer's disease: how gut microbiota modulate microglial function.

  • 2025-11-21
  • Review
  • Frontiers in aging 6
  • • Huan Wang
    • Feifan Yang
    • Zhejianyi Gao
    • Zedong Cheng
    • Xicai Liang

  • PubMed: 41356558
  • DOI: 10.3389/fragi.2025.1704047

  1 Insight on

  • Improved Cognitive Function

  • Low evidence

  This article reviews the direct and indirect effects of gut microbiota and its derivatives on microglia, explores their role in the pathogenesis of AD, and discusses therapeutic strategies based on gut microbiota, such as dietary regulation, probiotics, fecal microbiota transplantation, and traditional Chinese medicine.

  Effect

  Beneficial

  Effect size

  Small