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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus plantarum HEAL9 and Improved Cognitive Function

Research synthesisVery low evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral small-sized effect. The only statistically significant finding came from a meta-analysis with low certainty of evidence. Effects were predominantly small, and the evidence base is too limited to establish a clear dose range or most-studied population.

  • Studied populations: individuals over 18 years of age (from the meta-analysis) and adults over 70 with chronic low-grade inflammation (from the RCT)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The only statistically significant result came from a meta-analysis rated as low certainty of evidence, and the contributing studies were not all specific to Lactobacillus plantarum HEAL9. The neutral RCT did not reach significance. No form data were extracted, so it is unclear whether a specific formulation is required.

Generated Jun 11, 2026
Doses used in studies
  • CFU/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study
3 of 3 papers
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