Lactobacillus plantarum L-137 and Improved Immune Response

• Effects of Heat-Killed Lactobacillus plantarum L-137 Supplementation on Growth Performance, Blood Profiles, Intestinal Morphology, and Immune Gene Expression in Pigs

  • 2023-01-24
  • n = 100
  • Veterinary Sciences 10(2)
  • • W. Tartrakoon
    • Rangsun Charoensook
    • T. Incharoen
    • S. Numthuam
    • Thitima Pechrkong
    • S. Onoda
    • Gaku Shoji
    • B. Brenig

  • PubMed: 36851391
  • DOI: 10.3390/vetsci10020087

  3 Insights on

  • Improved Immune Response

  • Moderate evidence

  The relative mRNA expression level of *IFN- ß* of the suckling and starter pigs were significantly higher in the HKL1 and HKL2 groups than in the others (*p* < 0.05), while the *IFN-γ* showed the highest level in the HKL2 suckling pigs (*p* < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers.

  • 2022-08
  • RCT
  • Acta tropica 232
  • • Hai Ha Pham Thi
    • Tuong Vi Phan Thi
    • Ninh Pham Huynh
    • Vinh Doan
    • Satoru Onoda
    • Thanh Luan Nguyen

  • PubMed: 35623400
  • DOI: 10.1016/j.actatropica.2022.106537

  3 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  In contrast to bacitracin, a high dosage of L-137 significantly increased (p < 0.05) the spleen index value and the cytokine levels, as well as the expression of intestinal β-defensin genes on day 28.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Lactobacillus plantarum L-137 and/or β-glucan impacted the histopathological, antioxidant, immune-related genes and resistance of Nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila.

  • 2020-06
  • RCT
  • Research in Veterinary Science 130
  • • M. Dawood
    • E. Moustafa
    • Z. Elbialy
    • F. Farrag
    • Emad. E. Lolo
    • Hanaa A Abdel-Daim
    • Mohamed M. Abdel-Daim
    • Hien Van Doan

  • PubMed: 32203766
  • DOI: 10.1016/j.rvsc.2020.03.019

  14 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  both L-137 and BG helped Nile tilapia to have high phagocytosis activity and relative expression of tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) and interferon-gamma (INF-γ) genes.

  Effect

  Beneficial

  Effect size

  Moderate