Lactobacillus plantarum LP01 and Reduced Gastrointestinal Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus plantarum LP01 on reducing gastrointestinal symptoms, with moderate effect sizes in 2 studies and a small effect in the third. Two of the three studies found statistically significant improvements. The evidence primarily comes from clinical populations undergoing digestive surgery or bowel preparation, using a probiotic mixture containing LP01 at a dose of 1 billion living cells/day in one study.

Effective dose range: 1 billion living cells/day
Studied populations: patients undergoing digestive surgery, patients undergoing bowel preparation

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Two of the three studies evaluated LP01 in combination with other probiotic strains (Lactococcus lactis, Lactobacillus delbrueckii), making it difficult to isolate the specific effect of LP01 alone.

Generated May 12, 2026

Doses used in studies

cells/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study

Safety in these studies

Overall tolerabilityReported
the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing BP.
from: Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobac
Overall tolerabilityReported
Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing digestive surgery.
from: Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum

3 of 3 papers

Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01).
- 2019-07-10
- Clinical Trial
- Acta bio-medica : Atenei Parmensis 90(7-S)
- - Luigi Bonavina
  - Andrea Arini
  - Leonardo Ficano
  - Donato Iannuzziello
  - Luigi Pasquale
  - Salvo Emanuele Aragona
  - Giorgio Ciprandi
  - Italian Study Group On Digestive Disorders
- PubMed: 31292422
- DOI: 10.23750/abm.v90i7-s.8651
2 Insights on
- Reduced Gastrointestinal Symptoms
- Moderate evidence
Abincol® significantly diminished the presence and the severity of intestinal symptoms
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1 billion living cells/day
Is It Advisable to Use Probiotics Routinely After a Colonoscopy? A Rapid Comprehensive Review of the Evidence.
- 2025-06-09
- Review
- Medical sciences (Basel, Switzerland) 13(2)
- - Matteo Piciucchi
  - Alice Rossi
  - Alissa Satriano
  - Raffaele Manta
- PubMed: 40559234
- DOI: 10.3390/medsci13020076
1 Insight on
- Reduced Gastrointestinal Symptoms
- Low evidence
Some studies have positively evaluated the impact of the administration of different mixtures of probiotics in preventing and/or limiting this symptomatology.
Effect
Beneficial
Effect size
Small
Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation.
- 2019-07-10
- Observational
- Acta bio-medica : Atenei Parmensis 90(7-S)
- - Luigi Bonavina
  - Andrea Ariani
  - Leonardo Ficano
  - Domenico Iannuzziello
  - Luigi Pasquale
  - Salvo Emanuele Aragona
  - Lorenzo Drago
  - Giorgio Ciprandi
  - Italian Study Group On Digestive Disorders
- PubMed: 31292421
- DOI: 10.23750/abm.v90i7-s.8650
2 Insights on
- Reduced Gastrointestinal Symptoms
- Low evidence
Abincol® significantly diminished the presence and the severity of intestinal symptoms
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Lactobacillus plantarum LP01 and Reduced Gastrointestinal Symptoms

Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01).

Is It Advisable to Use Probiotics Routinely After a Colonoscopy? A Rapid Comprehensive Review of the Evidence.

Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation.