Lactobacillus plantarum LP01 and Reduced Gastrointestinal Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gastrointestinal symptoms, with effect sizes predominantly moderate (2 of 3 studies). The most studied dose was 1 billion living cells/day, used in a multi-strain probiotic mixture. Populations included patients undergoing digestive surgery or bowel preparation. Evidence is limited by a small number of studies and potential publication bias.

Effective dose range: 1 billion CFU/day (based on one study)
Studied populations: patients undergoing digestive surgery or bowel preparation

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, two of the three studies used a multi-strain product (Abincol®), making it difficult to attribute effects solely to Lactobacillus plantarum LP01.

Generated Jun 11, 2026

Doses used in studies

cells/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study

Safety in these studies

Overall tolerabilityReported
the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing BP.
from: Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobac
Overall tolerabilityReported
Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing digestive surgery.
from: Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum

3 of 3 papers

Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01).
- 2019-07-10
- Clinical Trial
- Acta bio-medica : Atenei Parmensis 90(7-S)
- - Luigi Bonavina
  - Andrea Arini
  - Leonardo Ficano
  - Donato Iannuzziello
  - Luigi Pasquale
  - Salvo Emanuele Aragona
  - Giorgio Ciprandi
  - Italian Study Group On Digestive Disorders
- PubMed: 31292422
- DOI: 10.23750/abm.v90i7-s.8651
2 Insights on
- Reduced Gastrointestinal Symptoms
- Moderate evidence
Abincol® significantly diminished the presence and the severity of intestinal symptoms
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1 billion living cells/day
Is It Advisable to Use Probiotics Routinely After a Colonoscopy? A Rapid Comprehensive Review of the Evidence.
- 2025-06-09
- Review
- Medical sciences (Basel, Switzerland) 13(2)
- - Matteo Piciucchi
  - Alice Rossi
  - Alissa Satriano
  - Raffaele Manta
- PubMed: 40559234
- DOI: 10.3390/medsci13020076
1 Insight on
- Reduced Gastrointestinal Symptoms
- Low evidence
Some studies have positively evaluated the impact of the administration of different mixtures of probiotics in preventing and/or limiting this symptomatology.
Effect
Beneficial
Effect size
Small
Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation.
- 2019-07-10
- Observational
- Acta bio-medica : Atenei Parmensis 90(7-S)
- - Luigi Bonavina
  - Andrea Ariani
  - Leonardo Ficano
  - Domenico Iannuzziello
  - Luigi Pasquale
  - Salvo Emanuele Aragona
  - Lorenzo Drago
  - Giorgio Ciprandi
  - Italian Study Group On Digestive Disorders
- PubMed: 31292421
- DOI: 10.23750/abm.v90i7-s.8650
2 Insights on
- Reduced Gastrointestinal Symptoms
- Low evidence
Abincol® significantly diminished the presence and the severity of intestinal symptoms
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Lactobacillus plantarum LP01 and Reduced Gastrointestinal Symptoms

Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01).

Is It Advisable to Use Probiotics Routinely After a Colonoscopy? A Rapid Comprehensive Review of the Evidence.

Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation.